Novel effect of adenosine 5 ′-ating hypertension and the metabolism of lipids and glucose in stroke-prone spontaneously hypertensive rats

Ardiansyah, Hitoshi Shirakawa, Takuya Koseki, Kazuyuki Hiwatashi, Saori Takahasi, Yoshinobu Akiyama, Michio Komai

    Research output: Contribution to journalArticlepeer-review

    9 Citations (Scopus)

    Abstract

    The aim of the study was to investigate the effects of adenosine 5′-monophosphate (AMP) in stroke-prone spontaneously hypertensive rats (SHRSP). Male rats (10 weeks old) were divided into three groups: a control group fed an AIN-93 M diet and two others fed supplemental AMP (17.5 and 87.5 mg/kg diet) for 3 weeks. AMP effectively improved hypertension, plasma triglyceride, and HDL-cholesterol, glucose, kidney function parameters, hepatic lipid, enhances plasma nitric oxide, and plasma adiponectin accompanied by the up-regulation of mRNA expression levels of the hepatic adiponectin receptor 2. Single and chronic oral administration of AMP affected the hepatic mRNA expression levels of genes involved in β-oxidation, fatty acid synthesis, and AMP-activated protein kinase. Furthermore, a single oral dose of AMP (40 mg/kg body weight) improved hypertension and hyperglycemia in SHRSP. In conclusion, AMP displays a novel effect in ameliorating metabolic-related diseases in SHRSP and could be beneficial as a functional food.

    Original languageEnglish
    Pages (from-to)13238-13245
    Number of pages8
    JournalJournal of Agricultural and Food Chemistry
    Volume59
    Issue number24
    DOIs
    Publication statusPublished - 2011 Dec 28

    Keywords

    • Adenosine monophosphate
    • glucose
    • hypertension
    • lipid
    • stroke-prone spontaneously hypertensive rats

    ASJC Scopus subject areas

    • Chemistry(all)
    • Agricultural and Biological Sciences(all)

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