Novel drug releasing system triggered by hybridization with target sequence.

Shizuka Nakayama, Fumi Nagatsugi, Shigeki Sasaki

Research output: Contribution to journalArticlepeer-review

Abstract

We have already established the strategy of synchronous activation by hybridization, in which the highly reactive cross-linking agent, 2-amino-6-vinylpurine nucleoside analog can be generated from its stable precursors, the phenylsulfide derivatives, by a hybridization-promoted activation process with selectivity to cytosine. In this study, this in situ activation system was applied to method for the drug releasing system triggered by hybridization with the target sequence.

Original languageEnglish
Pages (from-to)143-144
Number of pages2
JournalNucleic acids symposium series (2004)
Issue number50
DOIs
Publication statusPublished - 2006

ASJC Scopus subject areas

  • Medicine(all)

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