Novel drug releasing system triggered by hybridization with target sequence.

Shizuka Nakayama; Fumi Nagatsugi; Shigeki Sasaki

doi:10.1093/nass/nrl071

Novel drug releasing system triggered by hybridization with target sequence.

Shizuka Nakayama, Fumi Nagatsugi, Shigeki Sasaki

Division of Organic- and Biomaterials Research

Research output: Contribution to journal › Article › peer-review

Abstract

We have already established the strategy of synchronous activation by hybridization, in which the highly reactive cross-linking agent, 2-amino-6-vinylpurine nucleoside analog can be generated from its stable precursors, the phenylsulfide derivatives, by a hybridization-promoted activation process with selectivity to cytosine. In this study, this in situ activation system was applied to method for the drug releasing system triggered by hybridization with the target sequence.

Original language	English
Pages (from-to)	143-144
Number of pages	2
Journal	Nucleic acids symposium series (2004)
Issue number	50
DOIs	https://doi.org/10.1093/nass/nrl071
Publication status	Published - 2006

ASJC Scopus subject areas

Medicine(all)

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10.1093/nass/nrl071

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