TY - JOUR
T1 - Novel drug releasing system triggered by hybridization with target sequence.
AU - Nakayama, Shizuka
AU - Nagatsugi, Fumi
AU - Sasaki, Shigeki
N1 - Copyright:
This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine
PY - 2006
Y1 - 2006
N2 - We have already established the strategy of synchronous activation by hybridization, in which the highly reactive cross-linking agent, 2-amino-6-vinylpurine nucleoside analog can be generated from its stable precursors, the phenylsulfide derivatives, by a hybridization-promoted activation process with selectivity to cytosine. In this study, this in situ activation system was applied to method for the drug releasing system triggered by hybridization with the target sequence.
AB - We have already established the strategy of synchronous activation by hybridization, in which the highly reactive cross-linking agent, 2-amino-6-vinylpurine nucleoside analog can be generated from its stable precursors, the phenylsulfide derivatives, by a hybridization-promoted activation process with selectivity to cytosine. In this study, this in situ activation system was applied to method for the drug releasing system triggered by hybridization with the target sequence.
UR - http://www.scopus.com/inward/record.url?scp=36049037174&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=36049037174&partnerID=8YFLogxK
U2 - 10.1093/nass/nrl071
DO - 10.1093/nass/nrl071
M3 - Article
C2 - 17150858
AN - SCOPUS:36049037174
SP - 143
EP - 144
JO - Nucleic acids symposium series (2004)
JF - Nucleic acids symposium series (2004)
SN - 1746-8272
IS - 50
ER -