Novel dopamine D2 receptor signaling through proteins interacting with the third cytoplasmic loop

Kohji Fukunaga, Norifumi Shioda

Research output: Contribution to journalReview articlepeer-review

13 Citations (Scopus)


The diverse activities of dopamine D2-like receptors, including D2, D3, and D4 receptors, are mediated by proteins that interact with the third cytoplasmic loop and regulate receptor signaling, receptor trafficking, and apoptosis. Such interacting proteins include calmodulin, the N-methyl-d-aspartate receptor 2B subunit, calcium/calmodulin-dependent protein kinase II, prostate apoptosis response-4, and β-arrestins, which regulate receptor signaling and the pharmacological action through D2 receptor. The gene encoding the D2 receptor gives rise to two isoforms, termed the dopamine D2 receptor long isoform (D2L) and the dopamine D2 receptor short isoform; the latter lacks 29 amino acids of the D2L receptor within the third cytoplasmic loop. In this review, we first focus on novel functions of the hetero-oligomeric D1/D2 and D2/adenosine A 2A receptors. We next discuss novel signaling through proteins interacting with the D2 receptor third cytoplasmic loop and define the function of a novel binding protein, heart-type fatty acid binding protein, which interacts with the D2L third cytoplasmic loop.

Original languageEnglish
Pages (from-to)144-152
Number of pages9
JournalMolecular Neurobiology
Issue number1
Publication statusPublished - 2012 Feb


  • CaMKII
  • Dopamine D2 receptor
  • Heart-type fatty acid binding protein
  • Hetero-oligomeric D2 receptor

ASJC Scopus subject areas

  • Neurology
  • Cellular and Molecular Neuroscience


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