Novel Cytocidal Compounds, Oxopropalines from Streptomyces Sp. G324 Producing Lavendamycin II. Physico-Chemical Properties and Structure Elucidations

Abe Naoki, Enoki Nobuyasu, Nakakita Yasukazu, Uchida Hideaki, Nakamura Takehiko, Munekata Masanobu

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Novel cytocidal compounds designated oxopropalines A, B, D, E and G were isolated from the fermentation of an actinomycete namedStreptomyces sp. G324, a strain that also produced an antitumor antibiotic, lavendamycin. All these compounds possessed a β-carboline chromophore. The structures of the oxopropalines were elucidated by several NMRspectral analyses and other spectroscopic experiments.

Original languageEnglish
Pages (from-to)1678-1686
Number of pages9
JournalJournal of Antibiotics
Volume46
Issue number11
DOIs
Publication statusPublished - 1993 May
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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