In the course of our investigation aimed at the discovery of novel antitumor antibiotics from microorganisms, Streptomyces sp. G324 was found to produce the antitumor antibiotic, lavendamycin, and also, to yield the novel β-carboline compounds, oxopropalines. Weisolated five compoundsas oxopropalines A, B, D, E and G. Oxopropalines B, D and G showed cytocidal activities against humanor murine tumor cell lines in vitro.
ASJC Scopus subject areas
- Drug Discovery