Novel Cytocidal Compounds, Oxopropalines From Streptomyces Sp. G324 Producing Lavendamycin I. Taxonomy of the Producing Organism, Fermentation, Isolation and Biological Activities

Abe Naoki, Nakakita Yasukazu, Nakamura Takehiko, Enoki Nobuyasu, Uchida Hideaki, Takeo Suguru, Munekata Masanobu

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

In the course of our investigation aimed at the discovery of novel antitumor antibiotics from microorganisms, Streptomyces sp. G324 was found to produce the antitumor antibiotic, lavendamycin, and also, to yield the novel β-carboline compounds, oxopropalines. Weisolated five compoundsas oxopropalines A, B, D, E and G. Oxopropalines B, D and G showed cytocidal activities against humanor murine tumor cell lines in vitro.

Original languageEnglish
Pages (from-to)1672-1677
Number of pages6
JournalJournal of Antibiotics
Volume46
Issue number11
DOIs
Publication statusPublished - 1993 May
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Fingerprint

Dive into the research topics of 'Novel Cytocidal Compounds, Oxopropalines From Streptomyces Sp. G324 Producing Lavendamycin I. Taxonomy of the Producing Organism, Fermentation, Isolation and Biological Activities'. Together they form a unique fingerprint.

Cite this