Novel Cytocidal Compounds, Oxopropalines From Streptomyces Sp. G324 Producing Lavendamycin I. Taxonomy of the Producing Organism, Fermentation, Isolation and Biological Activities

Abe Naoki; Nakakita Yasukazu; Nakamura Takehiko; Enoki Nobuyasu; Uchida Hideaki; Takeo Suguru; Munekata Masanobu

doi:10.7164/antibiotics.46.1672

Novel Cytocidal Compounds, Oxopropalines From Streptomyces Sp. G324 Producing Lavendamycin I. Taxonomy of the Producing Organism, Fermentation, Isolation and Biological Activities

Abe Naoki, Nakakita Yasukazu, Nakamura Takehiko, Enoki Nobuyasu, Uchida Hideaki, Takeo Suguru, Munekata Masanobu

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

In the course of our investigation aimed at the discovery of novel antitumor antibiotics from microorganisms, Streptomyces sp. G324 was found to produce the antitumor antibiotic, lavendamycin, and also, to yield the novel β-carboline compounds, oxopropalines. Weisolated five compoundsas oxopropalines A, B, D, E and G. Oxopropalines B, D and G showed cytocidal activities against humanor murine tumor cell lines in vitro.

Original language	English
Pages (from-to)	1672-1677
Number of pages	6
Journal	Journal of Antibiotics
Volume	46
Issue number	11
DOIs	https://doi.org/10.7164/antibiotics.46.1672
Publication status	Published - 1993 May
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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Novel Cytocidal Compounds, Oxopropalines From Streptomyces Sp. G324 Producing Lavendamycin I. Taxonomy of the Producing Organism, Fermentation, Isolation and Biological Activities. / Naoki, Abe; Yasukazu, Nakakita; Takehiko, Nakamura; Nobuyasu, Enoki; Hideaki, Uchida; Suguru, Takeo; Masanobu, Munekata.

In: Journal of Antibiotics, Vol. 46, No. 11, 05.1993, p. 1672-1677.

Research output: Contribution to journal › Article › peer-review

Naoki, A, Yasukazu, N, Takehiko, N, Nobuyasu, E, Hideaki, U, Suguru, T & Masanobu, M 1993, 'Novel Cytocidal Compounds, Oxopropalines From Streptomyces Sp. G324 Producing Lavendamycin I. Taxonomy of the Producing Organism, Fermentation, Isolation and Biological Activities', Journal of Antibiotics, vol. 46, no. 11, pp. 1672-1677. https://doi.org/10.7164/antibiotics.46.1672

Naoki, Abe ; Yasukazu, Nakakita ; Takehiko, Nakamura ; Nobuyasu, Enoki ; Hideaki, Uchida ; Suguru, Takeo ; Masanobu, Munekata. / Novel Cytocidal Compounds, Oxopropalines From Streptomyces Sp. G324 Producing Lavendamycin I. Taxonomy of the Producing Organism, Fermentation, Isolation and Biological Activities. In: Journal of Antibiotics. 1993 ; Vol. 46, No. 11. pp. 1672-1677.

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AU - Suguru, Takeo

AU - Masanobu, Munekata

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Novel Cytocidal Compounds, Oxopropalines From Streptomyces Sp. G324 Producing Lavendamycin I. Taxonomy of the Producing Organism, Fermentation, Isolation and Biological Activities

Abstract

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