Novel cyclic peptide, epichlicin, from the endophytic fungus, Epichloe typhina

Yoshiya Seto, Kosaku Takahashi, Hideyuki Matsuura, Yasunori Kogami, Hiroshi Yada, Teruhiko Yoshihara, Kensuke Nabeta

    Research output: Contribution to journalArticlepeer-review

    37 Citations (Scopus)


    The novel cyclic peptide, epichlicin, was isolated from Epichloe typhina, an endophytic fungus of the timothy plant (Phleum pretense L.). Its structure was determined by NMR studies and by mass spectrometry. Enantiomers of 3-amino tetradecanoic acid, a constituent amino acid of epichlicin, were synthesized as authentic standards. The stereochemistry of each amino acid was elucidated through a combination of the advanced Marfey method and chemical manipulation. Epichlicin showed inhibitory activity toward the spore germination of Cladosporium phlei, a pathogenic fungus of the timothy plant at an IC 50 value of 22 nM.

    Original languageEnglish
    Pages (from-to)1470-1475
    Number of pages6
    JournalBioscience, Biotechnology and Biochemistry
    Issue number6
    Publication statusPublished - 2007


    • Cladosporium phlei
    • Cyclic peptide
    • Endophyte
    • Epichloe typhina
    • Germination inhibitor

    ASJC Scopus subject areas

    • Biotechnology
    • Analytical Chemistry
    • Biochemistry
    • Applied Microbiology and Biotechnology
    • Molecular Biology
    • Organic Chemistry


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