Novel cyclic peptide, epichlicin, from the endophytic fungus, Epichloe typhina

Yoshiya Seto, Kosaku Takahashi, Hideyuki Matsuura, Yasunori Kogami, Hiroshi Yada, Teruhiko Yoshihara, Kensuke Nabeta

    Research output: Contribution to journalArticlepeer-review

    30 Citations (Scopus)

    Abstract

    The novel cyclic peptide, epichlicin, was isolated from Epichloe typhina, an endophytic fungus of the timothy plant (Phleum pretense L.). Its structure was determined by NMR studies and by mass spectrometry. Enantiomers of 3-amino tetradecanoic acid, a constituent amino acid of epichlicin, were synthesized as authentic standards. The stereochemistry of each amino acid was elucidated through a combination of the advanced Marfey method and chemical manipulation. Epichlicin showed inhibitory activity toward the spore germination of Cladosporium phlei, a pathogenic fungus of the timothy plant at an IC 50 value of 22 nM.

    Original languageEnglish
    Pages (from-to)1470-1475
    Number of pages6
    JournalBioscience, Biotechnology and Biochemistry
    Volume71
    Issue number6
    DOIs
    Publication statusPublished - 2007

    Keywords

    • Cladosporium phlei
    • Cyclic peptide
    • Endophyte
    • Epichloe typhina
    • Germination inhibitor

    ASJC Scopus subject areas

    • Biotechnology
    • Analytical Chemistry
    • Biochemistry
    • Applied Microbiology and Biotechnology
    • Molecular Biology
    • Organic Chemistry

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