Novel blood–brain barrier-permeable spin probe for in vivo electron paramagnetic resonance imaging

Xiaolei Wang, Miho Emoto, Yusuke Miyake, Kaori Itto, Shu Xu, Hirotada Fujii, Hiroshi Hirata, Hirokazu Arimoto

    Research output: Contribution to journalArticle

    8 Citations (Scopus)

    Abstract

    A novel blood–brain barrier (BBB)-permeable compound 10 was discovered, wherein the nitroxide moiety was linked to a nicotine acetylcholine receptor ligand. It was applied as a probe for electron paramagnetic resonance (EPR) imaging of the mouse brain. The results demonstrated that the newly synthesized compound 10 exhibited BBB permeability. These findings provide an essential discovery for in vivo EPR imaging.

    Original languageEnglish
    Pages (from-to)4947-4949
    Number of pages3
    JournalBioorganic and Medicinal Chemistry Letters
    Volume26
    Issue number20
    DOIs
    Publication statusPublished - 2016 Jan 1

    Keywords

    • Blood–brain barrier permeable
    • EPR brain imaging
    • Nitroxide
    • Spin probe

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Medicine
    • Molecular Biology
    • Pharmaceutical Science
    • Drug Discovery
    • Clinical Biochemistry
    • Organic Chemistry

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