Novel blood–brain barrier-permeable spin probe for in vivo electron paramagnetic resonance imaging

Xiaolei Wang, Miho Emoto, Yusuke Miyake, Kaori Itto, Shu Xu, Hirotada Fujii, Hiroshi Hirata, Hirokazu Arimoto

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

A novel blood–brain barrier (BBB)-permeable compound 10 was discovered, wherein the nitroxide moiety was linked to a nicotine acetylcholine receptor ligand. It was applied as a probe for electron paramagnetic resonance (EPR) imaging of the mouse brain. The results demonstrated that the newly synthesized compound 10 exhibited BBB permeability. These findings provide an essential discovery for in vivo EPR imaging.

Original languageEnglish
Pages (from-to)4947-4949
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume26
Issue number20
DOIs
Publication statusPublished - 2016
Externally publishedYes

Keywords

  • Blood–brain barrier permeable
  • EPR brain imaging
  • Nitroxide
  • Spin probe

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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