Novel biological property of pertussis toxin: Chemotactic activity on human monocytes

Tomohiko Ogawa, Haruhiko Takada, Shozo Kotani, Hiroko Sato, Yuji Sato

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Pertussis toxin isolated from Bordetella pertussis phase I strain Tohama enhanced the migration of human blood monocytes in an assay with a multiwell chemotaxis assembly. The monocyte migration enhancement by pertussis toxin was abolished by heating at 100°C for 30 min, which caused a complete loss of the other biological activities of pertussis toxin. Checkerboard analysis demonstrated that the increased monocyte migration caused by pertussis toxin was directed toward a positive stimulus: chemotaxis.

Original languageEnglish
Pages (from-to)420-422
Number of pages3
JournalUnknown Journal
Volume41
Issue number1
DOIs
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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