TY - JOUR
T1 - Novel biological property of pertussis toxin
T2 - Chemotactic activity on human monocytes
AU - Ogawa, Tomohiko
AU - Takada, Haruhiko
AU - Kotani, Shozo
AU - Sato, Hiroko
AU - Sato, Yuji
PY - 1983
Y1 - 1983
N2 - Pertussis toxin isolated from Bordetella pertussis phase I strain Tohama enhanced the migration of human blood monocytes in an assay with a multiwell chemotaxis assembly. The monocyte migration enhancement by pertussis toxin was abolished by heating at 100°C for 30 min, which caused a complete loss of the other biological activities of pertussis toxin. Checkerboard analysis demonstrated that the increased monocyte migration caused by pertussis toxin was directed toward a positive stimulus: chemotaxis.
AB - Pertussis toxin isolated from Bordetella pertussis phase I strain Tohama enhanced the migration of human blood monocytes in an assay with a multiwell chemotaxis assembly. The monocyte migration enhancement by pertussis toxin was abolished by heating at 100°C for 30 min, which caused a complete loss of the other biological activities of pertussis toxin. Checkerboard analysis demonstrated that the increased monocyte migration caused by pertussis toxin was directed toward a positive stimulus: chemotaxis.
UR - http://www.scopus.com/inward/record.url?scp=0020582955&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020582955&partnerID=8YFLogxK
U2 - 10.1128/iai.41.1.420-422.1983
DO - 10.1128/iai.41.1.420-422.1983
M3 - Article
C2 - 6305846
AN - SCOPUS:0020582955
VL - 41
SP - 420
EP - 422
JO - [No source information available]
JF - [No source information available]
IS - 1
ER -
