TY - JOUR
T1 - Novel benzthiodiazepinones as antiherpetic agents
T2 - SAR improvement of therapeutic index by alterations of the seven-membered ring
AU - Hamilton, Harriet W.
AU - Nishiguchi, Gisele
AU - Hagen, Susan E.
AU - Domagala, John D.
AU - Weber, Peter C.
AU - Gracheck, Stephen
AU - Boulware, Stefanie L.
AU - Nordby, Eric C.
AU - Cho, Hidetsura
AU - Nakamura, Takeshi
AU - Ikeda, Satoru
AU - Watanabe, Wataru
PY - 2002/10/21
Y1 - 2002/10/21
N2 - A series of novel benzthiodiazepinones was studied as antiherpetic agents. Significant improvements in potency and therapeutic index in a viral replication assay were realized over the starting molecule. The role of stereospecific substitution on the diazepine ring and optimal nitrogen substitution were investigated.
AB - A series of novel benzthiodiazepinones was studied as antiherpetic agents. Significant improvements in potency and therapeutic index in a viral replication assay were realized over the starting molecule. The role of stereospecific substitution on the diazepine ring and optimal nitrogen substitution were investigated.
UR - http://www.scopus.com/inward/record.url?scp=18644383535&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=18644383535&partnerID=8YFLogxK
U2 - 10.1016/S0960-894X(02)00578-4
DO - 10.1016/S0960-894X(02)00578-4
M3 - Article
C2 - 12270188
AN - SCOPUS:18644383535
VL - 12
SP - 2981
EP - 2983
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 20
ER -