Novel benzthiodiazepinones as antiherpetic agents: SAR improvement of therapeutic index by alterations of the seven-membered ring

Harriet W. Hamilton, Gisele Nishiguchi, Susan E. Hagen, John D. Domagala, Peter C. Weber, Stephen Gracheck, Stefanie L. Boulware, Eric C. Nordby, Hidetsura Cho, Takeshi Nakamura, Satoru Ikeda, Wataru Watanabe

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

A series of novel benzthiodiazepinones was studied as antiherpetic agents. Significant improvements in potency and therapeutic index in a viral replication assay were realized over the starting molecule. The role of stereospecific substitution on the diazepine ring and optimal nitrogen substitution were investigated.

Original languageEnglish
Pages (from-to)2981-2983
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume12
Issue number20
DOIs
Publication statusPublished - 2002 Oct 21

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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