Novel aromatic substances, dictyomedin A and B, from Dictyostelium cellular slime molds and their inhibitory effects on Dictyostelium development

Yoshiaki Takaya, Haruhisa Kikuchi, Yuichi Terui, Jun Komiya, Yasuo Maeda, Akira Ito, Yoshiteru Oshima

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

To elucidate the diversity of secondary metabolites of Dictyostelium cellular slime molds and search for physiologically active substances affecting their development, we investigated the constituents of D. medium. From the methanol extract of its fruit body, we obtained two novel aromatic compounds named dictyomedin A (1) and B (2), and their structures were elucidated by means of physicochemical data. Biological evaluation of the compounds showed that they delayed the differentiation of D. discoideum cells.

Original languageEnglish
Pages (from-to)61-63
Number of pages3
JournalTetrahedron Letters
Volume42
Issue number1
DOIs
Publication statusPublished - 2001 Jan 1

Keywords

  • Cellular slime molds
  • Dibenzofuran
  • Dictyostelium medium
  • Differentiation inhibitor

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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