Streptomyces sp. HP530was found to produce novel antitumor antibiotics, saptomycins, closely related to the pluramycin-group and was further found to mutate frequently. The natural mutant produced several new saptomycins as determined by HPLCanalyses. We isolated saptomycins A, B, C1? C2 and F from the parent strain and saptomycins D, E, G and H from the mutant. The saptomycins showedantimicrobial activities and potent antitumor activities against humanor murine tumor cell lines in vitro and against Meth A fibrosarcoma in vivo. In particular, saptomycin D was most effective componentin vivo of all saptomycins.
ASJC Scopus subject areas
- Drug Discovery