Novel antitumor antibiotics, saptomycins i. taxonomy of the producing organism, fermentation, hplc analysis and biological activities

Abe Naoki, Nakakita Yasukazu, Nakamura Takehiko, Enoki Nobuyasu, Uchida Hideaki, Munekata Masanobu

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Streptomyces sp. HP530was found to produce novel antitumor antibiotics, saptomycins, closely related to the pluramycin-group and was further found to mutate frequently. The natural mutant produced several new saptomycins as determined by HPLCanalyses. We isolated saptomycins A, B, C1? C2 and F from the parent strain and saptomycins D, E, G and H from the mutant. The saptomycins showedantimicrobial activities and potent antitumor activities against humanor murine tumor cell lines in vitro and against Meth A fibrosarcoma in vivo. In particular, saptomycin D was most effective componentin vivo of all saptomycins.

Original languageEnglish
Pages (from-to)1530-1535
Number of pages6
Journalthe journal of antibiotics
Volume46
Issue number10
DOIs
Publication statusPublished - 1993 Feb
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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