Novel antimalarial guaiane-type sesquiterpenoids from Nardostachys chinensis roots

Yoshiaki Takaya, Ken Ichi Kurumada, Yoshie Takeuji, Hye Sook Kim, Yasuharu Shibata, Naomi Ikemoto, Yusuke Wataya, Yoshiteru Oshima

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38 Citations (Scopus)

Abstract

Three guaiane-type sesquiterpenoids, nardoperoxide (1a), isonardoperoxide (2a) and nardoxide (3), were isolated from Nardostachys chinensis roots. Their structures were elucidated by spectral means. Among them, two endoperoxides, nardoperoxide (1a) and isonardoperoxide (2a), showed strong antimalarial activity against Plasmodium falciparum malaria (EC50 1.5 x 10-6 and 6.0 x 10-7 M, respectively).

Original languageEnglish
Pages (from-to)1361-1364
Number of pages4
JournalTetrahedron Letters
Volume39
Issue number11
DOIs
Publication statusPublished - 1998 Mar 12

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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    Takaya, Y., Kurumada, K. I., Takeuji, Y., Kim, H. S., Shibata, Y., Ikemoto, N., Wataya, Y., & Oshima, Y. (1998). Novel antimalarial guaiane-type sesquiterpenoids from Nardostachys chinensis roots. Tetrahedron Letters, 39(11), 1361-1364. https://doi.org/10.1016/S0040-4039(97)10844-9