Novel [3+2] cycloaddition of alkylidenecyclopropanes with aldehydes catalyzed by palladium

Itaru Nakamura, Byoung Ho Oh, Shinichi Saito, Yoshinori Yamamoto

Research output: Contribution to journalArticlepeer-review

114 Citations (Scopus)

Abstract

Multiply substituted tetrahydrofuran rings can be prepared by the [3+2] cycloaddition of alkylidenecyclopropanes 1 with aldehydes 2 [Eq. (1)]. In this reaction, the distal bond of the cyclopropane ring is cleaved, and 3-methylenetetrahydrofuran derivatives 3 are produced in good yields.

Original languageEnglish
Pages (from-to)1298-1300
Number of pages3
JournalAngewandte Chemie - International Edition
Volume40
Issue number7
DOIs
Publication statusPublished - 2001 Apr 2

Keywords

  • Aldehydes
  • Cycloaddition heterocycles
  • Palladium
  • Synthetic methods

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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