Notch signaling and the determination of appendage identity

Shoichiro Kurata, Masahiro J. Go, Spyros Artavanis-Tsakonas, Walter J. Gehring

Research output: Contribution to journalArticlepeer-review

94 Citations (Scopus)


The Notch signaling pathway defines an evolutionarily conserved cell- cell interaction mechanism that throughout development controls the ability of precursor cells to respond to developmental signals. Here we show that Notch signaling regulates the expression of the master control genes eyeless, vestigial, and Distal-less, which in combination with homeotic genes induce the formation of eyes, wings, antennae, and legs. Therefore, Notch is involved in a common regulatory pathway for the determination of the various Drosophila appendages.

Original languageEnglish
Pages (from-to)2117-2122
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number5
Publication statusPublished - 2000 Feb 29


  • Appendage induction
  • Distal-less
  • Eyeless
  • Vestigial

ASJC Scopus subject areas

  • General


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