Normal sleep requires the astrocyte brain-type fatty acid binding protein FABP7

Jason R. Gerstner, Isaac J. Perron, Samantha M. Riedy, Takeo Yoshikawa, Hiroshi Kadotani, Yuji Owada, Hans P.A. Van Dongen, Raymond J. Galante, Kaitlin Dickinson, Jerry C.P. Yin, Allan I. Pack, Marcos G. Frank

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

Sleep is found widely in the animal kingdom. Despite this, few conserved molecular pathways that govern sleep across phyla have been described. The mammalian brain-type fatty acid binding protein (Fabp7) is expressed in astrocytes, and its mRNA oscillates in tandem with the sleep-wake cycle. However, the role of FABP7 in regulating sleep remains poorly understood. We found that the missense mutation FABP7.T61M is associated with fragmented sleep in humans. This phenotype was recapitulated in mice and fruitflies bearing similar mutations: Fabp7-deficient mice and transgenic flies that express the FABP7.T61M missense mutation in astrocytes also show fragmented sleep. These results provide novel evidence for a distinct molecular pathway linking lipid-signaling cascades within astrocytes in sleep regulation among phylogenetically disparate species.

Original languageEnglish
Article numbere1602663
JournalScience Advances
Volume3
Issue number4
DOIs
Publication statusPublished - 2017 Apr

ASJC Scopus subject areas

  • General

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