Normal organic and inorganic mercury levels in the human feto‐placental system

Tsuguyoshi Suzuki, Junzo Yonemoto, Hiroshi Satoh, Akira Naganuma, Nobumasa Imura, Tomonori Kigawa

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

To clarify the normal metabolism of mercurials in the human feto‐placental system, organic (or methyl) mercury and inorganic mercury were measured in maternal blood (MB), umbilical cord blood (UB), and chorionic tissues of the placenta (PC) and its blood vessels (PV), obtained from pregnant women just after delivery, as well as in fetal liver and fetal brain from induced abortion cases. Organic mercury was commonly detected in MB, UB, PC and PV, with slightly more elevated values in UB and PC than in MB, whereas inorganic mercury was detected in PC and PV, but not in MB and UB. In the fetal liver, 27–60% of mercury was in the form of inorganic mercury, whilst in four of five fetal brain samples, inorganic mercury was not detected. Additionally, fetal liver demethylation activity was studied in vitro. Incubation of methyl mercury with chopped fetal liver tissue for 24 h resulted in demethylation of approximately 1% of the methyl mercury.

Original languageEnglish
Pages (from-to)249-252
Number of pages4
JournalJournal of Applied Toxicology
Volume4
Issue number5
DOIs
Publication statusPublished - 1984 Oct

Keywords

  • fetus
  • humans
  • inorganic mercury
  • mercury metabolism
  • methylmercury
  • organic mercury
  • placenta

ASJC Scopus subject areas

  • Toxicology

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  • Cite this

    Suzuki, T., Yonemoto, J., Satoh, H., Naganuma, A., Imura, N., & Kigawa, T. (1984). Normal organic and inorganic mercury levels in the human feto‐placental system. Journal of Applied Toxicology, 4(5), 249-252. https://doi.org/10.1002/jat.2550040507