Nonlinear-microscopy optical-pulse sources based on mode-locked semiconductor lasers

H. Yokoyama, A. Sato, H. C. Guo, K. Sato, M. Mure, H. Tsubokawa

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)


We developed picosecond optical-pulse sources suitable for multiphoton microscopy based on mode-locked semiconductor lasers. Using external-cavity geometry, stable hybrid mode locking was achieved at a repetition rate of 500 MHz. Semiconductor optical amplifiers driven by synchronized electric pulses reached subharmonic optical-pulse repetition rates of 1-100 MHz. Two-stage Yb-doped fiber amplifiers produced optical pulses of 2 ps duration, with a peak power of a few kilowatts at a repetition rate of 10 MHz. These were employed successfully for nonlinear-optic bio-imaging using two-photon fluorescence, second-harmonic generation, and sum-frequency generation of synchronized two-color pulses.

Original languageEnglish
Pages (from-to)17752-17758
Number of pages7
JournalOptics Express
Issue number22
Publication statusPublished - 2008 Oct 27

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics


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