Noninvasive quantification of rCBF using positron emission tomography

H. Watabe, M. Itoh, V. Cunningham, A. A. Lammertsma, P. Bloomfield, M. Mejia, T. Fujiwara, A. K.P. Jones, T. Jones, T. Nakamura

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)


This study proposes a new method for the pixel-by-pixel quantification of regional CBF (rCBF) with positron emission tomography and H2/15O by using a reference tissue region. No arterial blood is required. Simulation studies revealed that the calculation of rCBF was fairly stable provided that the frame time was relatively short compared with total scan time. In practice, calculated CBF images correlated significantly with those obtained with the dynamic/integral method. Because the method accurately detects changes in CBF, it is particularly suitable for brain activation studies.

Original languageEnglish
Pages (from-to)311-319
Number of pages9
JournalJournal of Cerebral Blood Flow and Metabolism
Issue number2
Publication statusPublished - 1996


  • Noninvasive quantification
  • Positron emission tomography
  • Regional cerebral blood flow

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine


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