Noninvasive evaluation of cardiomyopathy by measuring thickness change in local myocardium

K. Sugimura, Hiroshi Kanai, N. Chubachi, Y. Tsukahara, Y. Koiwa, H. Kamada, F. Tezuka

Research output: Contribution to journalArticlepeer-review

Abstract

In order to diagnose heart disease, we have developed a method for transcutaneously measuring and analyzing small velocity signals of the heart wall using ultrasound and conducted experiments in vivo clearly showing differences between results obtained from healthy human subjects and those obtained from patients with serious cases of doxorubicin cardiomyopathy. It is necessary to investigate the relationship between the above results obtained by noninvasive measurement and the pathological findings from actual myocardial tissue. Because it is highly invasive and imposes a high load, however, repeated biopsy in human patients is difficult. In this study, therefore, small velocity signals on both sides of the interventricular septum (IVS) were measured noninvasively, and change in thickness of the IVS during one cardiac cycle was evaluated for healthy rabbits (controls) (n = 5) and rabbits with drug-induced cardiomyopathy after administration of anthracycline carcinostatic for periods of about 5 (n = 3) and 10 weeks (n = 2). The experimental results confirmed that average ratio of maximum change in thickness of the IVS during one cardiac cycle to thickness at the time of R-wave (ECG) decreased from 1/4 for controls to 1/8 for those medicated for about 10-weeks as total dose of anthracycline carcinostatic was increased. On the other hand, average percent damage of myocardial tissue in the IVS increased from 0.1% in the controls to 38.7% for the 10-week group. We therefore conclude that there is clear a relationship between measurement results obtained using ultrasound and the pathological findings.

Original languageEnglish
Pages (from-to)23-29
Number of pages7
JournalJournal of Medical Ultrasonics
Volume25
Issue number5
Publication statusPublished - 1998 Jan 1

Keywords

  • Doxorubicin cardiomyopathy
  • Heart wall vibration
  • Local myocardial thickening
  • Phased tracking
  • Ultrasonic transcutaneous measurement

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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