Nonapoptotic functions of caspases: caspases as regulatory molecules for immunity and cell-fate determination

Erina Kuranaga, Masayuki Miura

Research output: Contribution to journalReview articlepeer-review

159 Citations (Scopus)

Abstract

Caspases are a family of cysteine proteases that are highly conserved in multicellular organisms and function as central regulators of apoptosis. Recent investigations in Caenorhabditis elegans, Drosophila and mice suggest that caspases also function as regulatory molecules for immunity and cell-fate determination. Here, we review genetic studies of nonapoptotic functions of caspases and discuss the regulatory mechanisms of caspases for executing nonapoptotic functions.

Original languageEnglish
Pages (from-to)135-144
Number of pages10
JournalTrends in Cell Biology
Volume17
Issue number3
DOIs
Publication statusPublished - 2007 Mar
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology

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