Non-invasive three-dimensional power Doppler imaging for the assessment of acute cerebral blood flow alteration in a mouse model of subarachnoid haemorrhage

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1 Citation (Scopus)

Abstract

We aimed to evaluate the feasibility of a non-invasive method of cerebral blood flow (CBF) measurement using high-frequency power Doppler ultrasound imaging in a mouse model of subarachnoid haemorrhage (SAH). The 3-dimensionally (3D) reconstructed blood flow signals (%vascularity) within the brain volume of the middle cerebral artery territory correlated well with reference parameters, baseline carotid artery blood flow (r2= 0.52, P < 0.0001) and normalized CBF changes (r2= 0.74 P < 0.0001). These data suggest that the 3D power Doppler analysis may have the potential for reflecting real-time CBF changes during the acute phase of experimental SAH, which may be applicable to preclinical studies on early brain injury.

Original languageEnglish
Pages (from-to)99-102
Number of pages4
JournalClinical and Experimental Pharmacology and Physiology
Volume46
Issue number1
DOIs
Publication statusPublished - 2019 Jan

Keywords

  • cerebral blood flow
  • mouse model
  • subarachnoid haemorrhage
  • ultrasound imaging

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

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