Non-invasive measurement of blood glucose by attenuated total reflection spectroscopy with fixed-wavelength quantum cascade lasers

Takuya Koyama, Saiko Kino, Yuji Matsuura

Research output: Contribution to journalConference articlepeer-review

Abstract

For non-invasive blood glucose measurement, a measurement system based on mid-infrared ATR spectroscopy equipped with a combination of quantum cascade lasers (QCLs) as light sources and hollow-optical fibers as a beam delivery media is developed. Firstly the optical absorption of human lips in the mid-infrared wavelength region is measured using FT-IR. The spectrum shows the wavenumber of 1152 cm"1 exhibits strong absorption of glucose. Then we also confirmed that there is no absorption at the wavenumber of 1186 cm"1 from the spectrum of glucose solution. Finally we measured absorption of human lips using the QCL with these wavelengths. As a result, the measured differential absorption follows the change of blood glucose well and the correlation factor between the absorbance and the blood glucose level is 0.55.

Original languageEnglish
Article number1114001-186
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume11140
Publication statusPublished - 2019 Jan 1
EventBiomedical Imaging and Sensing Conference 2019, BISC 2019 - Yokohama, Japan
Duration: 2019 Apr 222019 Apr 26

Keywords

  • ATR spectroscopy
  • Blood glucose
  • Hollow optical fiber
  • Quantum cascade laser

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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