Non-invasive imaging of radiocesium dynamics in a living animal using a positron-emitting 127Cs tracer

Nobuo Suzui, Takuya Shibata, Yong Gen Yin, Yoshihito Funaki, Keisuke Kurita, Hiroyuki Hoshina, Mitsutaka Yamaguchi, Shu Fujimaki, Noriaki Seko, Hiroshi Watabe, Naoki Kawachi

Research output: Contribution to journalArticlepeer-review

Abstract

Visualizing the dynamics of cesium (Cs) is desirable to understand the impact of radiocesium when accidentally ingested or inhaled by humans. However, visualization of radiocesium in vivo is currently limited to plants. Herein, we describe a method for the production and purification of 127Cs and its use in visualizing Cs dynamics in a living animal. The positron-emitting nuclide 127Cs was produced using the 127I (α, 4n) 127Cs reaction, which was induced by irradiation of sodium iodide with a 4He2+ beam from a cyclotron. We excluded sodium ions by using a material that specifically adsorbs Cs as a purification column and successfully eluted 127Cs by flowing a solution of ammonium sulfate into the column. We injected the purified 127Cs tracer solution into living rats and the dynamics of Cs were visualized using positron emission tomography; the distributional images showed the same tendency as the results of previous studies using disruptive methods. Thus, this method is useful for the non-invasive investigation of radiocesium in a living animal.

Original languageEnglish
Article number16155
JournalScientific reports
Volume10
Issue number1
DOIs
Publication statusPublished - 2020 Dec 1

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Non-invasive imaging of radiocesium dynamics in a living animal using a positron-emitting <sup>127</sup>Cs tracer'. Together they form a unique fingerprint.

Cite this