Non-invasive blood glucose measurement using fixed-wavelength quantum cascade lasers

T. Koyama, S. Kino, Yuji Matsuura

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

An ATR measurement system composed of hollow optical fibers, a trapezoid multi-reflection prism, and a couple of fixed-wavelength QCLs emitting different wavelengths is proposed for non-invasive measurement of blood glucose. To choose a wavelength combination that is appropriate for measurement of glucose absorption, firstly absorption spectra of human lip mucosa measured by using an FT-IR-based ATR system are investigated. As a result, two wavelengths, 1152 cm-1 that coincides with an absorption peak of glucose, and 1186 cm-1 where the glucose absorption becomes minimum are chosen. From numerical simulation using spectral absorptions measured by the FT-IR system, it is found that the differential absorption between the above wavelengths shows a good correlation to blood glucose levels. Finally in-vivo measurement using the ATR system equipped with two single-wavelength QCLs is performed and it is found that the measured optical absorption follows the blood glucose well.

Original languageEnglish
Title of host publicationOptical Fibers and Sensors for Medical Diagnostics and Treatment Applications XIX
EditorsIsrael Gannot, Israel Gannot
PublisherSPIE
ISBN (Electronic)9781510623866
DOIs
Publication statusPublished - 2019 Jan 1
EventOptical Fibers and Sensors for Medical Diagnostics and Treatment Applications XIX 2019 - San Francisco, United States
Duration: 2019 Feb 22019 Feb 3

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume10872
ISSN (Print)1605-7422

Conference

ConferenceOptical Fibers and Sensors for Medical Diagnostics and Treatment Applications XIX 2019
CountryUnited States
CitySan Francisco
Period19/2/219/2/3

Keywords

  • ATR spectroscopy
  • Blood glucose
  • Hollow optical fiber
  • Quantum cascade laser

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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