Non-erosive GERD

Michio Hongo, Daisaku Tamura

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)


Non-erosive reflux disease (NERD) is defined as those who have typical reflux symptoms without evidence of erosive changes in their lower esophageal mucosa. Symptoms should occur more than twice a week, and esophageal mucosa should be free from erosion. However, the differentiation from normal might be difficult because of the ambiguous definition. Pathophysiological mechanism on heartburn is not simply acidic stimuli to esophageal mucosa, but also esophageal distention, hypersensitive esophagus and/or exaggerate perception. NERD is not a simply milder form of reflux disease, because they have poor response to pharmacotherapy. Based on such evidence, newer concept for NERD is required.

Original languageEnglish
Pages (from-to)1565-1569
Number of pages5
JournalNippon rinsho. Japanese journal of clinical medicine
Issue number8
Publication statusPublished - 2004 Aug

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Non-erosive GERD'. Together they form a unique fingerprint.

Cite this