Non-cell autonomous and non-catalytic activities of ATX in the developing brain

Raanan Greenman, Anna Gorelik, Tamar Sapir, Jan Baumgart, Vanessa Zamor, Michal Segal-Salto, Smadar Levin-Zaidman, Vassilis Aidinis, Junken Aoki, Robert Nitsch, Johannes Vogt, Orly Reiner

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

The intricate formation of the cerebral cortex requires a well-coordinated series of events, which are regulated at the level of cell-autonomous and non-cell autonomous mechanisms. Whereas cell-autonomous mechanisms that regulate cortical development are well-studied, the non-cell autonomous mechanisms remain poorly understood. A non-biased screen allowed us to identify Autotaxin (ATX) as a non-cell autonomous regulator of neural stem cells. ATX (also known as ENPP2) is best known to catalyze lysophosphatidic acid (LPA) production. Our results demonstrate that ATX affects the localization and adhesion of neuronal progenitors in a cell autonomous and non-cell autonomous manner, and strikingly, this activity is independent from its catalytic activity in producing LPA.

Original languageEnglish
Article number53
JournalFrontiers in Neuroscience
Volume9
Issue numberMAR
DOIs
Publication statusPublished - 2015 Mar 4

Keywords

  • Autotaxin
  • Cortical development
  • In utero electroporation
  • LPA
  • Neuronal stem cell
  • Radial glia

ASJC Scopus subject areas

  • Neuroscience(all)

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