NOD Mice with High Incidence of Type 1 Diabetes are not T Lymphocytopenic

Jo Satoh, Shigeki Shintani, Takayoshi Toyota, Yoshio Goto, Toshima Nobunaga, Shunji Sugawara, Susumu Makino

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

An autoimmune pathogenesis has been indicated in insulin-dependent (type 1) diabetes mellitus (IDDM). Previously we reported that non-obese diabetic (NOD) mice as an animal model of spontaneously developing IDDM were immunologically characterized by T lymphocytopenia and impaired cellular immunities. The cumulative incidence of diabetes in the T lymphocytopenic female NOD mice was 10-20% by 24 weeks of age. On the other hand, the incidence of diabetes are 80-90% in the female NOD/Shi-Sendai (S), in whom proportion of lymophocyte subsets has not been known yet. Therefore, we examined the spleen cells of female NOD/Shi-S and female NOD/Shi with high incidence of diabetes, and of female Jcl : ICR as a control. Cell numbers, populations of T cells (Thy 1.2+, Lyt-1+ and Lyt-2+), B cells (surface-Ig+), NK cells (acialo GM1+) and responsiveness to Concanavalin A were analyzed as immunological parameters. In contrast to the T lymphocytopenic NOD, these immunological parameters were not impaired in the NOD/Shi-S and NOD/Shi in comparison to those of Jcl : ICR. The results indicate that there may be a positive association between the incidence of diabetes and T cell number and functions in female NOD mice.

Original languageEnglish
Pages (from-to)151-158
Number of pages8
Journalthe tohoku journal of experimental medicine
Volume155
Issue number2
DOIs
Publication statusPublished - 1988 Jan 1

Keywords

  • NOD mice
  • T lymphocyte
  • cellular immunity
  • insulin-dependent diabetes mellitus (IDDM)

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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