Nocturnal blood pressure dip in CADASIL

Y. Manabe, T. Murakami, K. Iwatsuki, H. Narai, H. Warita, T. Hayashi, M. Shoji, Y. Imai, K. Abe

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

The influence of a nocturnal blood pressure dip on cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) has not yet been clarified. We attempted to examine a correlation with the nocturnal blood pressure dip and CADASIL. We monitored circadian blood pressure patterns by the use of a portable blood pressure monitoring device in five patients with CADASIL and 10 age- and sex-matched control subjects. Based on nocturnal fall in mean arterial blood pressure (MABP), we classified patients into extreme dippers (nocturnal reduction of MABP ≥20%), dippers (≥10% but <20%), nondippers (<10% but ≥0%), and inverted dippers (<0%). Three patients revealed non-dipper and two inverted dipper. Nighttime MABP fall was significantly lower in patients compared with control subjects (P<0.01). This study suggests that a lower nocturnal blood pressure fall may be partly associated with incidence and/or worsening of deep white matter lesions in CADASIL.

Original languageEnglish
Pages (from-to)13-16
Number of pages4
JournalJournal of the neurological sciences
Volume193
Issue number1
DOIs
Publication statusPublished - 2001 Dec 15

Keywords

  • Ambulatory blood pressure monitoring
  • CADASIL
  • Inverted dipper
  • Non-dipper

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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