Abstract
We have recently reported that nobiletin, a citrus flavonoid, improves impaired memory in olfactory-bulbectomized (OBX) mice, which have been widely utilized as a useful paradigm that shares some major clinical features of Alzheimer's disease. Here, we examined the effects of nobiletin on OBX-induced cholinergic neurodegeneration in mice. OBX mice showed reduced acetylcholinesterase (AChE) staining and choline acetyltransferase (ChAT) expression in the hippocampus. An 11-day administration of nobiletin rescued OBX-induced decrease in the density of AChE-staining and ChAT expression in the hippocampus. These results suggest that nobiletin rescues OBX-induced cholinergic neurodegeneration, accompanied by improvement of impaired memory in OBX mice.
Original language | English |
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Pages (from-to) | 122-126 |
Number of pages | 5 |
Journal | Journal of Pharmacological Sciences |
Volume | 105 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2007 |
Externally published | Yes |
Keywords
- Alzheimer's disease
- Cholinergic neuron
- Nobiletin
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology