Nobiletin, a citrus flavonoid that improves memory impairment, rescues bulbectomy-induced cholinergic neurodegeneration in mice

Akira Nakajima, Tohru Yamakuni, Mitsuya Haraguchi, Naoki Omae, Si Young Song, Chieko Kato, Osamu Nakagawasai, Takeshi Tadano, Akihito Yokosuka, Yoshihiro Mimaki, Yutaka Sashida, Yasushi Ohizumi

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

We have recently reported that nobiletin, a citrus flavonoid, improves impaired memory in olfactory-bulbectomized (OBX) mice, which have been widely utilized as a useful paradigm that shares some major clinical features of Alzheimer's disease. Here, we examined the effects of nobiletin on OBX-induced cholinergic neurodegeneration in mice. OBX mice showed reduced acetylcholinesterase (AChE) staining and choline acetyltransferase (ChAT) expression in the hippocampus. An 11-day administration of nobiletin rescued OBX-induced decrease in the density of AChE-staining and ChAT expression in the hippocampus. These results suggest that nobiletin rescues OBX-induced cholinergic neurodegeneration, accompanied by improvement of impaired memory in OBX mice.

Original languageEnglish
Pages (from-to)122-126
Number of pages5
JournalJournal of Pharmacological Sciences
Volume105
Issue number1
DOIs
Publication statusPublished - 2007 Sep 28

Keywords

  • Alzheimer's disease
  • Cholinergic neuron
  • Nobiletin

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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  • Cite this

    Nakajima, A., Yamakuni, T., Haraguchi, M., Omae, N., Song, S. Y., Kato, C., Nakagawasai, O., Tadano, T., Yokosuka, A., Mimaki, Y., Sashida, Y., & Ohizumi, Y. (2007). Nobiletin, a citrus flavonoid that improves memory impairment, rescues bulbectomy-induced cholinergic neurodegeneration in mice. Journal of Pharmacological Sciences, 105(1), 122-126. https://doi.org/10.1254/jphs.SC0070155