Nobiletin, a citrus flavonoid that improves memory impairment, rescues bulbectomy-induced cholinergic neurodegeneration in mice

Akira Nakajima; Tohru Yamakuni; Mitsuya Haraguchi; Naoki Omae; Si Young Song; Chieko Kato; Osamu Nakagawasai; Takeshi Tadano; Akihito Yokosuka; Yoshihiro Mimaki; Yutaka Sashida; Yasushi Ohizumi

doi:10.1254/jphs.SC0070155

Nobiletin, a citrus flavonoid that improves memory impairment, rescues bulbectomy-induced cholinergic neurodegeneration in mice

Akira Nakajima, Tohru Yamakuni, Mitsuya Haraguchi, Naoki Omae, Si Young Song, Chieko Kato, Osamu Nakagawasai, Takeshi Tadano, Akihito Yokosuka, Yoshihiro Mimaki, Yutaka Sashida, Yasushi Ohizumi

PHA - Life and Pharmaceutical Science

Research output: Contribution to journal › Article

105 Citations (Scopus)

Abstract

We have recently reported that nobiletin, a citrus flavonoid, improves impaired memory in olfactory-bulbectomized (OBX) mice, which have been widely utilized as a useful paradigm that shares some major clinical features of Alzheimer's disease. Here, we examined the effects of nobiletin on OBX-induced cholinergic neurodegeneration in mice. OBX mice showed reduced acetylcholinesterase (AChE) staining and choline acetyltransferase (ChAT) expression in the hippocampus. An 11-day administration of nobiletin rescued OBX-induced decrease in the density of AChE-staining and ChAT expression in the hippocampus. These results suggest that nobiletin rescues OBX-induced cholinergic neurodegeneration, accompanied by improvement of impaired memory in OBX mice.

Original language	English
Pages (from-to)	122-126
Number of pages	5
Journal	Journal of Pharmacological Sciences
Volume	105
Issue number	1
DOIs	https://doi.org/10.1254/jphs.SC0070155
Publication status	Published - 2007 Sep 28

Keywords

Alzheimer's disease
Cholinergic neuron
Nobiletin

ASJC Scopus subject areas

Molecular Medicine
Pharmacology

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Nakajima, A., Yamakuni, T., Haraguchi, M., Omae, N., Song, S. Y., Kato, C., Nakagawasai, O., Tadano, T., Yokosuka, A., Mimaki, Y., Sashida, Y., & Ohizumi, Y. (2007). Nobiletin, a citrus flavonoid that improves memory impairment, rescues bulbectomy-induced cholinergic neurodegeneration in mice. Journal of Pharmacological Sciences, 105(1), 122-126. https://doi.org/10.1254/jphs.SC0070155

Nobiletin, a citrus flavonoid that improves memory impairment, rescues bulbectomy-induced cholinergic neurodegeneration in mice. / Nakajima, Akira; Yamakuni, Tohru; Haraguchi, Mitsuya; Omae, Naoki; Song, Si Young; Kato, Chieko; Nakagawasai, Osamu; Tadano, Takeshi; Yokosuka, Akihito; Mimaki, Yoshihiro; Sashida, Yutaka; Ohizumi, Yasushi.

In: Journal of Pharmacological Sciences, Vol. 105, No. 1, 28.09.2007, p. 122-126.

Research output: Contribution to journal › Article

Nakajima, A, Yamakuni, T, Haraguchi, M, Omae, N, Song, SY, Kato, C, Nakagawasai, O, Tadano, T, Yokosuka, A, Mimaki, Y, Sashida, Y & Ohizumi, Y 2007, 'Nobiletin, a citrus flavonoid that improves memory impairment, rescues bulbectomy-induced cholinergic neurodegeneration in mice', Journal of Pharmacological Sciences, vol. 105, no. 1, pp. 122-126. https://doi.org/10.1254/jphs.SC0070155

Nakajima, Akira ; Yamakuni, Tohru ; Haraguchi, Mitsuya ; Omae, Naoki ; Song, Si Young ; Kato, Chieko ; Nakagawasai, Osamu ; Tadano, Takeshi ; Yokosuka, Akihito ; Mimaki, Yoshihiro ; Sashida, Yutaka ; Ohizumi, Yasushi. / Nobiletin, a citrus flavonoid that improves memory impairment, rescues bulbectomy-induced cholinergic neurodegeneration in mice. In: Journal of Pharmacological Sciences. 2007 ; Vol. 105, No. 1. pp. 122-126.

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