No evidence for association between the interferon regulatory factor 1 (IRF1) gene and clinical tuberculosis

Sabine Vollstedt, Rika Yuliwulandari, Koji Okamoto, Luu Thi Lien, Naoto Keicho, Jecti Teguh Rochani, Riyani Wikaningrum, Katsushi Tokunaga

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Interferon regulatory factor 1 is a transcription factor involved in initiating a vigorous Th1 response during Mycobacterium tuberculosis infection. Therefore, we considered it as a possible candidate gene for certain polymorphisms to confer susceptibility to develop clinical tuberculosis. However, all polymorphisms with minor allele frequencies higher than 5% and haplotype frequencies in two Southeast Asian populations (Indonesian and Vietnamese) turned out not to be associated with pulmonary tuberculosis.

Original languageEnglish
Pages (from-to)71-76
Number of pages6
JournalTuberculosis
Volume89
Issue number1
DOIs
Publication statusPublished - 2009 Jan 1
Externally publishedYes

Keywords

  • Interferon regulatory factor 1 (IRF1)
  • Tuberculosis

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases

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