No Desensitization of the Growth Hormone (GH) Response between GH-Releasing Peptide-2 and GH-Releasing Factor in Calves

S. G. Roh, M. L. He, N. Matsunaga, S. Hidaka, H. Hidari

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We investigated the desensitization caused by growth hormone (GH)-releasing peptide-2 (D-Ala-D-βNal-Ala-Trp-D-Phe-Lys-NH2; GHRP-2) in vivo using calves. The GHRP-2 (12.5μg·kgBW-1·h-1) or GH-releasing factor (GRF; .125 μg·kgBW-1·h-1) were infused for 180 min into four calves, each followed by either GHRP-2 (12.5 μg/kg BW) or GRF (.125 μg/kg BW) injection after 60 min. All treatments were given to all of the calves. The continuous infusion of GHRP-2 did not attenuate the GH secretion caused by a GRF bolus, and vice versa. Continuous exposure to GHRP-2 attenuated the GH secretion caused by a GHRP-2 bolus. In an additional experiment, two repetitive injections of GHRP-2 (12.5 μg/kg BW) at 1-, 2-, 3-, or 4-h intervals were administered. Attenuation of the GH response caused by GHRP-2 was maintained until 4 h. These results suggest that GHRP-2 is not cross-desensitized with GRF and that the mechanisms by which they cause GH release may be different in calves.

Original languageEnglish
Pages (from-to)2749-2753
Number of pages5
JournalJournal of animal science
Volume75
Issue number10
DOIs
Publication statusPublished - 1997 Oct
Externally publishedYes

Keywords

  • Cattle
  • Growth Hormone
  • Hypothalamic Releasing Hormones
  • Pituitary Gland

ASJC Scopus subject areas

  • Food Science
  • Animal Science and Zoology
  • Genetics

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