No Association between CEL-HYB Hybrid Allele and Chronic Pancreatitis in Asian Populations

Wen Bin Zou, Arnaud Boulling, Atsushi Masamune, Prachand Issarapu, Emmanuelle Masson, Hao Wu, Xiao Tian Sun, Liang Hao Hu, Dai Zhan Zhou, Lin He, Yann Fichou, Eriko Nakano, Shin Hamada, Yoichi Kakuta, Kiyoshi Kume, Hiroyuki Isayama, Sumit Paliwal, K. Radha Mani, Seema Bhaskar, David N. CooperClaude Férec, Tooru Shimosegawa, Giriraj R. Chandak, Jian Min Chen, Zhao Shen Li, Zhuan Liao

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)

Abstract

A hybrid allele between the carboxyl ester lipase gene (CEL) and its pseudogene, CELP (called CEL-HYB), generated by nonallelic homologous recombination between CEL intron 10 and CELP intron 10′, was found to increase susceptibility to chronic pancreatitis in a case-control study of patients of European ancestry. We attempted to replicate this finding in 3 independent cohorts from China, Japan, and India, but failed to detect the CEL-HYB allele in any of these populations. The CEL-HYB allele might therefore be an ethnic-specific risk factor for chronic pancreatitis. An alternative hybrid allele (CEL-HYB2) was identified in all 3 Asian populations (1.7% combined carrier frequency), but was not associated with chronic pancreatitis.

Original languageEnglish
Pages (from-to)1558-1560.e5
JournalGastroenterology
Volume150
Issue number7
DOIs
Publication statusPublished - 2016 Jun 1

Keywords

  • Disease Susceptibility
  • Human Genetics
  • Nonsense-Mediated mRNA Decay
  • Pancreatic Acinar Cells

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Fingerprint

Dive into the research topics of 'No Association between CEL-HYB Hybrid Allele and Chronic Pancreatitis in Asian Populations'. Together they form a unique fingerprint.

Cite this