NMR spectroscopic analyses of functional nucleic acids-metal interaction and their solution structure analyses.

Yoshiyuki Tanaka, Hiroshi Yamaguchi, Shuji Oda, Chojiro Kojima, Akira Ono, Kazunari Taira, Yoshinori Kondo

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

We have studied complexations of functional nucleic acids and metal ions, by means of NMR spectroscopy. In the case of hammerhead ribozymes, they have a metal ion-binding motif in their core sequences. Upon the metallation of N7 of a guanosine in an RNA duplex modelled after hammerhead ribozymes, 20 ppm higher field shift of N7 was observed in 1-dimensional (1D) 15N NMR spectra. It was found that metal ion binding to nucleobases were detectable with 15N NMR spectroscopy.

Original languageEnglish
Pages (from-to)51-52
Number of pages2
JournalNucleic acids symposium series (2004)
Issue number49
DOIs
Publication statusPublished - 2005

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'NMR spectroscopic analyses of functional nucleic acids-metal interaction and their solution structure analyses.'. Together they form a unique fingerprint.

Cite this