NKG2D in NK and T cell-mediated immunity

Kouetsu Ogasawara, Lewis L. Lanier

Research output: Contribution to journalReview articlepeer-review

86 Citations (Scopus)

Abstract

One of the best characterized NK cell receptors is NKG2D, a highly conserved C-type lectin-like membrane glycoprotein expressed on essentially all NK cells, as well as on γδ-TcR+ T cells and αβ-TcR+ CD8+ T cells, in humans and mice. Here we review recent studies implicating NKG2D in T cell and NK cell-mediated immunity to viruses and tumors, and its potential role in autoimmune diseases and allogeneic bone marrow transplantation.

Original languageEnglish
Pages (from-to)534-540
Number of pages7
JournalJournal of Clinical Immunology
Volume25
Issue number6
DOIs
Publication statusPublished - 2005 Nov 1
Externally publishedYes

Keywords

  • Autoimmunity
  • Bone marrow transplantation
  • DAP10
  • MICA
  • NK cells
  • NKG2D
  • RAE-1
  • T cell

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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