Abstract
One of the best characterized NK cell receptors is NKG2D, a highly conserved C-type lectin-like membrane glycoprotein expressed on essentially all NK cells, as well as on γδ-TcR+ T cells and αβ-TcR+ CD8+ T cells, in humans and mice. Here we review recent studies implicating NKG2D in T cell and NK cell-mediated immunity to viruses and tumors, and its potential role in autoimmune diseases and allogeneic bone marrow transplantation.
Original language | English |
---|---|
Pages (from-to) | 534-540 |
Number of pages | 7 |
Journal | Journal of Clinical Immunology |
Volume | 25 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2005 Nov |
Externally published | Yes |
Keywords
- Autoimmunity
- Bone marrow transplantation
- DAP10
- MICA
- NK cells
- NKG2D
- RAE-1
- T cell
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology