NKG2D in NK and T cell-mediated immunity

Kouetsu Ogasawara; Lewis L. Lanier

doi:10.1007/s10875-005-8786-4

NKG2D in NK and T cell-mediated immunity

Kouetsu Ogasawara, Lewis L. Lanier

Research output: Contribution to journal › Review article › peer-review

86 Citations (Scopus)

Abstract

One of the best characterized NK cell receptors is NKG2D, a highly conserved C-type lectin-like membrane glycoprotein expressed on essentially all NK cells, as well as on γδ-TcR⁺ T cells and αβ-TcR⁺ CD8⁺ T cells, in humans and mice. Here we review recent studies implicating NKG2D in T cell and NK cell-mediated immunity to viruses and tumors, and its potential role in autoimmune diseases and allogeneic bone marrow transplantation.

Original language	English
Pages (from-to)	534-540
Number of pages	7
Journal	Journal of Clinical Immunology
Volume	25
Issue number	6
DOIs	https://doi.org/10.1007/s10875-005-8786-4
Publication status	Published - 2005 Nov 1
Externally published	Yes

Keywords

Autoimmunity
Bone marrow transplantation
DAP10
MICA
NK cells
NKG2D
RAE-1
T cell

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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AB - One of the best characterized NK cell receptors is NKG2D, a highly conserved C-type lectin-like membrane glycoprotein expressed on essentially all NK cells, as well as on γδ-TcR+ T cells and αβ-TcR+ CD8+ T cells, in humans and mice. Here we review recent studies implicating NKG2D in T cell and NK cell-mediated immunity to viruses and tumors, and its potential role in autoimmune diseases and allogeneic bone marrow transplantation.

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KW - Bone marrow transplantation

KW - DAP10

KW - MICA

KW - NK cells

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KW - RAE-1

KW - T cell

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