NK cells in innate immunity

Jessica A. Hamerman, Kouetsu Ogasawara, Lewis L. Lanier

Research output: Contribution to journalReview articlepeer-review

227 Citations (Scopus)

Abstract

NK cells have an important role in innate immune responses, particularly in anti-viral immunity. Recent studies have revealed a molecular basis for NK cell recognition of virus-infected cells, implicating the activating KIR and Ly49 receptors and NKG2D in this process. Additionally, mutual cooperation between NK cells and dendritic cells suggests that these innate cells can shape the nature of an adaptive immune response. These findings, as well as advances in understanding NK cell development and homeostasis, indicate that NK cell biology is more sophisticated than previously appreciated.

Original languageEnglish
Pages (from-to)29-35
Number of pages7
JournalCurrent Opinion in Immunology
Volume17
Issue number1
DOIs
Publication statusPublished - 2005 Feb
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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