Nitrogen-directed ortho-arylation and -heteroarylation of aromatic rings catalyzed by ruthenium complexes

Shuichi Oi, Raito Funayama, Tetsutaro Hattori, Yoshio Inoue

Research output: Contribution to journalArticlepeer-review

84 Citations (Scopus)

Abstract

The ruthenium-catalyzed direct ortho-arylation reactions of 2-phenylpyridine and 2-aryloxazolines have been successfully expanded to the direct aryl-heteroaryl coupling reactions using heteroaryl bromides. The reaction mechanism involving the RuII/RuIV intermediates is proposed from the results of the stoichiometric reaction of a divalent ruthenacycle complex of 2-phenylpyridine with bromobenzene.

Original languageEnglish
Pages (from-to)6051-6059
Number of pages9
JournalTetrahedron
Volume64
Issue number26
DOIs
Publication statusPublished - 2008 Jun 23

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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