Nitric oxide in the kidney

S. Ito

Research output: Contribution to journalReview articlepeer-review

44 Citations (Scopus)


Nitric oxide seems to play a crucial role in sodium homeostasis and hence blood pressure regulation by controlling the tone of glomerular arterioles and mesangium, medullary circulation, pressure natriuresis, tubuloglomerular feedback, renin release, and tubular function. Thus, deficiency of the L-arginine-nitric oxide pathway may be involved in the pathogenesis of such diseases as salt-sensitive hypertension, whereas activation of the nitric oxide system may either protect against or contribute to progression of various renal diseases.

Original languageEnglish
Pages (from-to)23-30
Number of pages8
JournalCurrent Opinion in Nephrology and Hypertension
Issue number1
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Internal Medicine
  • Nephrology


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