Nicotine infusion into rat ventromedial nuclei and effect on monoaminergic system

Eduardo J.B. Ramos, Michael M. Meguid, Lihua Zhang, Go Miyata, Serguei O. Fetissov, Chung Chen, Susumu Suzuki, Alessandro Laviano

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Nicotine increases satiety and reduces food intake (Fl). We hypothesize that nicotine influences Fl via alteration of serotonin (5HT) and dopamine (DA) concentration in ventromedial nucleus (VMN) and lateral hypothalamic area (LHA). Microdialysis cannulas were implanted into ipsilateral VMN and contralateral LHA. Nicotine or vehicle was infused for 60 min into VMN of overnight food-deprived rats, followed by ad lib food for 40 min. Hypothalamic changes in 5HT and DA concentrations were measured every 20 min. Intra-VMN nicotine induced a long-lasting increase in 5HT concentration and an increase in DA for a short duration in the VMN, associated with an increase in 5HT in the LHA. Our data suggest that the nicotine-induced hypophagia correlates with VMN and LHA monoaminergic changes.

Original languageEnglish
Pages (from-to)2293-2297
Number of pages5
Issue number14
Publication statusPublished - 2004 Oct 5


  • Dopamine
  • Food intake
  • Lateral hypothalamic area
  • Nicotine
  • Serotonin
  • Ventromedial nucleus

ASJC Scopus subject areas

  • Neuroscience(all)


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