Nicotine improves cognitive disturbance in rodents fed with a choline-deficient diet

H. Sasaki, M. Yanai, K. Meguro, K. Sekizawa, Y. Ikarashi, Y. Maruyama, M. Yamamoto, Y. Matsuzaki, T. Takishima

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


The effect of nicotine on learning disturbances was tested in rats. Rats were fed either a choline-enriched or a choline-deficient diet. Concentration of acetylcholine in the whole brain was significantly lower in rats fed with choline-deficient diet than rats fed with choline-enriched diet. Passive avoidance learning shows that rats on a choline-deficient diet showed significantly impaired learning compared to rats on a choline-enriched diet. Nicotine (0.04 mg/kg) administered intraperitoneally significantly potentiated learning in rats on a choline-deficient diet, as well as in rats on a choline-enriched diet. We, therefore, suggest that nicotine may potentiate learning in an acetylcholine-deprived brain.

Original languageEnglish
Pages (from-to)921-925
Number of pages5
JournalPharmacology, Biochemistry and Behavior
Issue number4
Publication statusPublished - 1991 Apr


  • Acetylcholine
  • Alzheimer's disease
  • Nicotine
  • Rat
  • Tobacco

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience


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