Nicotine improves cognitive disturbance in rodents fed with a choline-deficient diet

H. Sasaki; M. Yanai; K. Meguro; K. Sekizawa; Y. Ikarashi; Y. Maruyama; M. Yamamoto; Y. Matsuzaki; T. Takishima

doi:10.1016/0091-3057(91)90265-4

Nicotine improves cognitive disturbance in rodents fed with a choline-deficient diet

H. Sasaki, M. Yanai, K. Meguro, K. Sekizawa, Y. Ikarashi, Y. Maruyama, M. Yamamoto, Y. Matsuzaki, T. Takishima

New Industry Creation Hatchery Center (NICHe)

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

The effect of nicotine on learning disturbances was tested in rats. Rats were fed either a choline-enriched or a choline-deficient diet. Concentration of acetylcholine in the whole brain was significantly lower in rats fed with choline-deficient diet than rats fed with choline-enriched diet. Passive avoidance learning shows that rats on a choline-deficient diet showed significantly impaired learning compared to rats on a choline-enriched diet. Nicotine (0.04 mg/kg) administered intraperitoneally significantly potentiated learning in rats on a choline-deficient diet, as well as in rats on a choline-enriched diet. We, therefore, suggest that nicotine may potentiate learning in an acetylcholine-deprived brain.

Original language	English
Pages (from-to)	921-925
Number of pages	5
Journal	Pharmacology, Biochemistry and Behavior
Volume	38
Issue number	4
DOIs	https://doi.org/10.1016/0091-3057(91)90265-4
Publication status	Published - 1991 Apr

Keywords

Acetylcholine
Alzheimer's disease
Nicotine
Rat
Tobacco

ASJC Scopus subject areas

Biochemistry
Toxicology
Pharmacology
Clinical Biochemistry
Biological Psychiatry
Behavioral Neuroscience

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title = "Nicotine improves cognitive disturbance in rodents fed with a choline-deficient diet",

abstract = "The effect of nicotine on learning disturbances was tested in rats. Rats were fed either a choline-enriched or a choline-deficient diet. Concentration of acetylcholine in the whole brain was significantly lower in rats fed with choline-deficient diet than rats fed with choline-enriched diet. Passive avoidance learning shows that rats on a choline-deficient diet showed significantly impaired learning compared to rats on a choline-enriched diet. Nicotine (0.04 mg/kg) administered intraperitoneally significantly potentiated learning in rats on a choline-deficient diet, as well as in rats on a choline-enriched diet. We, therefore, suggest that nicotine may potentiate learning in an acetylcholine-deprived brain.",

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AU - Sasaki, H.

AU - Yanai, M.

AU - Meguro, K.

AU - Sekizawa, K.

AU - Ikarashi, Y.

AU - Maruyama, Y.

AU - Yamamoto, M.

AU - Matsuzaki, Y.

AU - Takishima, T.

PY - 1991/4

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N2 - The effect of nicotine on learning disturbances was tested in rats. Rats were fed either a choline-enriched or a choline-deficient diet. Concentration of acetylcholine in the whole brain was significantly lower in rats fed with choline-deficient diet than rats fed with choline-enriched diet. Passive avoidance learning shows that rats on a choline-deficient diet showed significantly impaired learning compared to rats on a choline-enriched diet. Nicotine (0.04 mg/kg) administered intraperitoneally significantly potentiated learning in rats on a choline-deficient diet, as well as in rats on a choline-enriched diet. We, therefore, suggest that nicotine may potentiate learning in an acetylcholine-deprived brain.

AB - The effect of nicotine on learning disturbances was tested in rats. Rats were fed either a choline-enriched or a choline-deficient diet. Concentration of acetylcholine in the whole brain was significantly lower in rats fed with choline-deficient diet than rats fed with choline-enriched diet. Passive avoidance learning shows that rats on a choline-deficient diet showed significantly impaired learning compared to rats on a choline-enriched diet. Nicotine (0.04 mg/kg) administered intraperitoneally significantly potentiated learning in rats on a choline-deficient diet, as well as in rats on a choline-enriched diet. We, therefore, suggest that nicotine may potentiate learning in an acetylcholine-deprived brain.

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KW - Alzheimer's disease

KW - Nicotine

KW - Rat

KW - Tobacco

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Nicotine improves cognitive disturbance in rodents fed with a choline-deficient diet

Abstract

Keywords

ASJC Scopus subject areas

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