Abstract
A new diphosphine (POP) ligand bearing an alkoxide group allows us to synthesize partially fluorinated arenes. A nickel-catalyzed cross-coupling between a polyfluoroarene and an organozinc reagent in the presence of POP selectively produces a monosubstitution product. Aryl and alkylzinc reagents smoothly take part in the reaction. It is speculated that monosubstitution is the result of accelerated product expulsion from the product/catalyst complex.
Original language | English |
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Pages (from-to) | 3316-3319 |
Number of pages | 4 |
Journal | Organic letters |
Volume | 14 |
Issue number | 13 |
DOIs | |
Publication status | Published - 2012 Jul 6 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry