Nicaraven prevents the fast growth of inflamed tumors by an anti-inflammatory mechanism

Lina Abdelghany, Xu Zhang, Tsuyoshi Kawabata, Shinji Goto, Nageh El-Mahdy, Keiichi Jingu, Tao Sheng Li

Research output: Contribution to journalArticlepeer-review

Abstract

Inflammatory microenvironment is known to accelerate the progression of malignant tumors. We investigated the possible anti-inflammatory effect of nicaraven on slowing tumor growth. Tumor-bearing mice randomly received nicaraven injection (50 mg/kg daily, i.p, n = 8) or placebo treatment (n = 8) for 10 days, and then sacrificed for evaluations. Nicaraven administration effectively inhibited the fast growth of tumor, as a large tumor (> 1.0 g) developed finally in three of the eight mice received placebo treatment. Cytokines/chemokines array indicated that nicaraven reduced the levels of CXCL10 and SDF-1 in the tumor as well as the levels of IL-2 and MIP-2 in serum. Immunofluorescence staining showed that nicaraven significantly reduced the recruitment of macrophages and neutrophils in the tumor. Interestingly, western blot indicated that the expression of CD86, CD206, and NIMP-R14 was especially enhanced in the three large-size tumors, suggesting the potential role of nicaraven in preventing the hyper-inflammatory tumor microenvironment. Moreover, the expression of PARP-1 was downregulated, but the expression of phospho-p38 MAPK, phospho-MKK-3/6, and phospho-MSK-1 was upregulated in the large-size tumors, suggesting the involvement of p38 MAPK pathway in the anti-inflammatory effect of nicaraven. Taken together, our study suggests that nicaraven may effectively prevent the fast growth of inflamed tumors by an anti-inflammatory mechanism.

Original languageEnglish
Article number7
JournalMedical Oncology
Volume39
Issue number1
DOIs
Publication statusPublished - 2022 Jan

Keywords

  • Chemokines
  • Cytokines
  • Inflammatory cells
  • Nicaraven
  • Tumor microenvironment

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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