Ni-free Zr-Cu-Al-Nb-Pd bulk metallic glasses with different Zr/Cu ratios for biomedical applications

Lu Huang, Yoshihiko Yokoyama, Wei Wu, Peter K. Liaw, Shujie Pang, Akihisa Inoue, Tao Zhang, Wei He

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


Zr-based bulk metallic glasses (BMGs) possess attractive properties for prospective biomedical applications. The present study designs Ni-free Zr-Cu-Al-Nb-Pd BMGs and investigates their in vitro biocompatibility by studying mechanical properties, bio-corrosion resistance, and cellular responses. The Ti-6Al-4V alloy is used as a reference material. It is found that the Zr-based BMGs exhibit good mechanical properties, including high strengths above 1600 MPa, high hardness over 4700 MPa, and low elastic moduli of 85-90 GPa. The Zr-based BMGs are corrosion resistant in a simulated body environment, as revealed by wide passive regions, low passive current densities, and high pitting overpotentials. The formation of ZrO 2-rich surface passive films of the Zr-based BMGs contributes to their high corrosion resistance, whereas their pitting corrosion in the phosphate buffered saline solution can be attributed to the sensitivity of the ZrO 2 films to the chloride ion. The general biosafety of the Zr-based BMGs is revealed by normal cell adhesions and cell morphologies. Moreover, the Zr/Cu content ratio in the alloy composition affects the biocompatibility of the Zr-based BMGs, by increasing their corrosion resistance and surface wettability with the increase of the Zr/Cu ratio. Effects of Zr/Cu ratios can be used to guide the future design of biocompatible Zr-based BMGs.

Original languageEnglish
Pages (from-to)1472-1482
Number of pages11
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume100 B
Issue number6
Publication statusPublished - 2012 Aug


  • biocompatibility
  • bulk metallic glass
  • cell adhesion
  • corrosion
  • mechanical properties

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering


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