New weighting methods for phylogenetic tree reconstruction using multiple loci

Kazuharu Misawa, Fumio Tajima

Research output: Contribution to journalArticlepeer-review

Abstract

Efficient determination of evolutionary distances is important for the correct reconstruction of phylogenetic trees. The performance of the pooled distance required for reconstructing a phylogenetic tree can be improved by applying large weights to appropriate distances for reconstructing phylogenetic trees and small weights to inappropriate distances. We developed two weighting methods, the modified Tajima-Takezaki method and the modified least-squares method, for reconstructing phylogenetic trees from multiple loci. By computer simulations, we found that both of the new methods were more efficien in reconstructing correct topologies than the no-weight method. Hence, we reconstructed hominoid phylogenetic trees from mitochondrial DNA using our new methods, and found that the levels of bootstrap support were significantly increased by the modified Tajima-Takezaki and by the modified least-squares method.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalJournal of Molecular Evolution
Volume75
Issue number1-2
DOIs
Publication statusPublished - 2012 Aug

Keywords

  • Computer simulation
  • Phylogeny reconstruction
  • Weighting methods

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics

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