New synthetic routes to synthons for the synthesis of functionalized aspidosperma alkaloids

Seiichi Takano, Kozo Shishido, Masaaki Sato, Kohtaro Yuta, Kunio Ogasawara

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

The diazoketones (3a and b) and the iminomalonates (7a and b) have been converted into the tetracyclic vinylogous amides (6a and b) by an acid-catalysed single-step reaction; Birch reduction of the amides (6a and b) afforded the corresponding tetracyclic ketones (2a and b), synthons for the synthesis of functionalized aspidosperma alkaloids.

Original languageEnglish
Pages (from-to)943-944
Number of pages2
JournalJournal of the Chemical Society, Chemical Communications
Issue number21
DOIs
Publication statusPublished - 1978

ASJC Scopus subject areas

  • Molecular Medicine

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