TY - JOUR
T1 - New small γ-turn type
T2 - N -primary amino terminal tripeptide organocatalyst for solvent-free asymmetric aldol reaction of various ketones with aldehydes
AU - Thiyagarajan, Rajkumar
AU - Begum, Zubeda
AU - Seki, Chigusa
AU - Okuyama, Yuko
AU - Kwon, Eunsang
AU - Uwai, Koji
AU - Tokiwa, Michio
AU - Tokiwa, Suguru
AU - Takeshita, Mitsuhiro
AU - Nakano, Hiroto
N1 - Publisher Copyright:
© The Royal Society of Chemistry.
PY - 2021/12/6
Y1 - 2021/12/6
N2 - New small γ-turn type N-primary amino terminal tripeptides were synthesized and their functionality as an organocatalyst was examined in the asymmetric aldol reaction of various ketones with different aromatic aldehydes under solvent-free neat conditions to afford the desired chiral anti-aldol products in good to excellent chemical yields, diastereoselectivities and enantioselectivities (up to 99%, up to syn : anti/13 : 87 dr, up to 99% ee).
AB - New small γ-turn type N-primary amino terminal tripeptides were synthesized and their functionality as an organocatalyst was examined in the asymmetric aldol reaction of various ketones with different aromatic aldehydes under solvent-free neat conditions to afford the desired chiral anti-aldol products in good to excellent chemical yields, diastereoselectivities and enantioselectivities (up to 99%, up to syn : anti/13 : 87 dr, up to 99% ee).
UR - http://www.scopus.com/inward/record.url?scp=85121272633&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85121272633&partnerID=8YFLogxK
U2 - 10.1039/d1ra08635a
DO - 10.1039/d1ra08635a
M3 - Article
AN - SCOPUS:85121272633
SN - 2046-2069
VL - 11
SP - 38925
EP - 38932
JO - RSC Advances
JF - RSC Advances
IS - 61
ER -