New Rev-export inhibitor from Alpinia galanga and structure-activity relationship

Satoru Tamura, Atsushi Shiomi, Masafumi Kaneko, Ying Ye, Minoru Yoshida, Masayuki Yoshikawa, Tominori Kimura, Motomasa Kobayashi, Nobutoshi Murakami

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

Bioassay-guided separation by use of the fission yeast expressing NES of Rev, an HIV-1 viral regulatory protein, disclosed 1′-acetoxychavicol acetate (ACA, 1) as a new inhibitor for nuclear export of Rev from the roots of Alpinia galanga. Both analysis for mechanism of action with biotinylated probe (2) and several synthesized analogs established crucial portions in 1 for Rev-export inhibitory activity.

Original languageEnglish
Pages (from-to)2555-2557
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number9
DOIs
Publication statusPublished - 2009 May 1

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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