New Rev-export inhibitor from Alpinia galanga and structure-activity relationship

Satoru Tamura; Atsushi Shiomi; Masafumi Kaneko; Ying Ye; Minoru Yoshida; Masayuki Yoshikawa; Tominori Kimura; Motomasa Kobayashi; Nobutoshi Murakami

doi:10.1016/j.bmcl.2009.03.047

New Rev-export inhibitor from Alpinia galanga and structure-activity relationship

Satoru Tamura, Atsushi Shiomi, Masafumi Kaneko, Ying Ye, Minoru Yoshida, Masayuki Yoshikawa, Tominori Kimura, Motomasa Kobayashi, Nobutoshi Murakami

SCI - Chemistry

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Bioassay-guided separation by use of the fission yeast expressing NES of Rev, an HIV-1 viral regulatory protein, disclosed 1′-acetoxychavicol acetate (ACA, 1) as a new inhibitor for nuclear export of Rev from the roots of Alpinia galanga. Both analysis for mechanism of action with biotinylated probe (2) and several synthesized analogs established crucial portions in 1 for Rev-export inhibitory activity.

Original language	English
Pages (from-to)	2555-2557
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	9
DOIs	https://doi.org/10.1016/j.bmcl.2009.03.047
Publication status	Published - 2009 May 1

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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New Rev-export inhibitor from Alpinia galanga and structure-activity relationship. / Tamura, Satoru; Shiomi, Atsushi; Kaneko, Masafumi; Ye, Ying; Yoshida, Minoru; Yoshikawa, Masayuki; Kimura, Tominori; Kobayashi, Motomasa; Murakami, Nobutoshi.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 19, No. 9, 01.05.2009, p. 2555-2557.

Research output: Contribution to journal › Article › peer-review

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abstract = "Bioassay-guided separation by use of the fission yeast expressing NES of Rev, an HIV-1 viral regulatory protein, disclosed 1′-acetoxychavicol acetate (ACA, 1) as a new inhibitor for nuclear export of Rev from the roots of Alpinia galanga. Both analysis for mechanism of action with biotinylated probe (2) and several synthesized analogs established crucial portions in 1 for Rev-export inhibitory activity.",

author = "Satoru Tamura and Atsushi Shiomi and Masafumi Kaneko and Ying Ye and Minoru Yoshida and Masayuki Yoshikawa and Tominori Kimura and Motomasa Kobayashi and Nobutoshi Murakami",

note = "Funding Information: This work was supported in part by Grants-in-Aid for Scientific Research (Grant No. 19590100) from the Ministry of Education, Science, Culture and Sports. The authors are grateful to the Naito Foundation and the Takeda Science Foundation for financial support.",

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AU - Tamura, Satoru

AU - Shiomi, Atsushi

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AU - Yoshida, Minoru

AU - Yoshikawa, Masayuki

AU - Kimura, Tominori

AU - Kobayashi, Motomasa

AU - Murakami, Nobutoshi

N1 - Funding Information: This work was supported in part by Grants-in-Aid for Scientific Research (Grant No. 19590100) from the Ministry of Education, Science, Culture and Sports. The authors are grateful to the Naito Foundation and the Takeda Science Foundation for financial support.

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