TY - JOUR
T1 - New Rev-export inhibitor from Alpinia galanga and structure-activity relationship
AU - Tamura, Satoru
AU - Shiomi, Atsushi
AU - Kaneko, Masafumi
AU - Ye, Ying
AU - Yoshida, Minoru
AU - Yoshikawa, Masayuki
AU - Kimura, Tominori
AU - Kobayashi, Motomasa
AU - Murakami, Nobutoshi
N1 - Funding Information:
This work was supported in part by Grants-in-Aid for Scientific Research (Grant No. 19590100) from the Ministry of Education, Science, Culture and Sports. The authors are grateful to the Naito Foundation and the Takeda Science Foundation for financial support.
PY - 2009/5/1
Y1 - 2009/5/1
N2 - Bioassay-guided separation by use of the fission yeast expressing NES of Rev, an HIV-1 viral regulatory protein, disclosed 1′-acetoxychavicol acetate (ACA, 1) as a new inhibitor for nuclear export of Rev from the roots of Alpinia galanga. Both analysis for mechanism of action with biotinylated probe (2) and several synthesized analogs established crucial portions in 1 for Rev-export inhibitory activity.
AB - Bioassay-guided separation by use of the fission yeast expressing NES of Rev, an HIV-1 viral regulatory protein, disclosed 1′-acetoxychavicol acetate (ACA, 1) as a new inhibitor for nuclear export of Rev from the roots of Alpinia galanga. Both analysis for mechanism of action with biotinylated probe (2) and several synthesized analogs established crucial portions in 1 for Rev-export inhibitory activity.
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U2 - 10.1016/j.bmcl.2009.03.047
DO - 10.1016/j.bmcl.2009.03.047
M3 - Article
C2 - 19342232
AN - SCOPUS:64249097969
VL - 19
SP - 2555
EP - 2557
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 9
ER -
