New recommendations for vancomycin dosage for patients with MRSA pneumonia with various degrees of renal function impairment

Makiko Yoshida, Noriko Yasuda, Mayumi Nishikata, Kanami Okamoto, Takahiro Uchida, Kenji Matsuyama

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

New recommendations for vancomycin (VCM) dosages and dosing intervals for MRSA-infected pneumonia patients with various degrees of renal function impairment were established based on Japanese population pharmacokinetic parameters proposed by Yasuhara et al. in 1998. Based on individual creatinine clearance (CLcr), we proposed the optimum VCM dosages and dosing intervals so that the peak level of VCM (level at 1h after the end of infusion) is maintained in the range of 25-40μg/ml and the trough level is kept under 15μg/ml. The recommended doses and intervals of VCM were as follows: 20mg/kg every 12h for CLcr of 80-100ml/min, 18mg/kg every 12h for CLcr of 70ml/min, 25mg/kg every 24h for CLcr of 50-60ml/min, 22mg/kg every 36h for CLcr of 40ml/min, and 18mg/kg every 48h for CLcr of 30ml/min. Using the recorded pharmacokinetic parameters of VCM from eight patients with pneumonia who were admitted to Aoyama Second Hospital between November 1997 and January 2002, these recommendations were used in computer simulations for the eight patients, and the usefulness of these recommendations was confirmed.

Original languageEnglish
Pages (from-to)182-188
Number of pages7
JournalJournal of Infection and Chemotherapy
Volume11
Issue number4
DOIs
Publication statusPublished - 2005 Jan 1
Externally publishedYes

Keywords

  • Dosage
  • MRSA pneumonia
  • Methicillin-resistant Staphylococcus aureus (MRSA)
  • Optimal dosage regimen
  • Renal function
  • Vancomycin

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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