New orally active PDE4 inhibitors with therapeutic potential

Hiroshi Ochiai, Akiharu Ishida, Tazumi Ohtani, Kensuke Kusumi, Katuya Kishikawa, Takaaki Obata, Hisao Nakai, Masaaki Toda

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Structural optimization of pyrazolopyridine derivative 2, which is one of the newly discovered chemical leads for PDE4 inhibitors from our in-house library, was carried out successfully. The process of discovery of new orally active PDE4 inhibitors, which are expected to possess therapeutic potential, is presented and their structure-activity relationships are discussed.

Original languageEnglish
Pages (from-to)29-32
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number1
Publication statusPublished - 2004 Jan 5
Externally publishedYes


  • Inhibitor
  • Orally active
  • PDE4
  • Pyrazolopyrioline

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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