New myrsinol diterpenes from Euphorbia prolifera and their inhibitory activities on LPS-induced NO production

Jing Xu, Da Qing Jin, Yuanqiang Guo, Chunfeng Xie, Yonggang Ma, Tohru Yamakuni, Yasushi Ohizumi

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

A phytochemical investigation of the roots of Euphorbia prolifera led to the isolation of ten new myrsinol diterpenes, named euphorbialoids A-J (1-10), and two known analogues (11 and 12). Their structures were elucidated on the basis of extensive 1D and 2D NMR (COSY, HMQC, HMBC and NOESY) spectroscopic data analyzes, and the structures of 1 and 9 were confirmed by X-ray crystallography. The inhibitory activities on LPS-induced NO production of these diterpenes were evaluated and all the compounds showed inhibitory effects.

Original languageEnglish
Pages (from-to)3612-3618
Number of pages7
JournalBioorganic and Medicinal Chemistry Letters
Volume22
Issue number11
DOIs
Publication statusPublished - 2012 Jun 1

Keywords

  • Euphorbia prolifera
  • Inhibitory activities on NO production
  • Myrsinol diterpene

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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