New myrsinol diterpenes from Euphorbia prolifera and their inhibitory activities on LPS-induced NO production

Jing Xu; Da Qing Jin; Yuanqiang Guo; Chunfeng Xie; Yonggang Ma; Tohru Yamakuni; Yasushi Ohizumi

doi:10.1016/j.bmcl.2012.04.052

New myrsinol diterpenes from Euphorbia prolifera and their inhibitory activities on LPS-induced NO production

Jing Xu, Da Qing Jin, Yuanqiang Guo, Chunfeng Xie, Yonggang Ma, Tohru Yamakuni, Yasushi Ohizumi

PHA - Life and Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

A phytochemical investigation of the roots of Euphorbia prolifera led to the isolation of ten new myrsinol diterpenes, named euphorbialoids A-J (1-10), and two known analogues (11 and 12). Their structures were elucidated on the basis of extensive 1D and 2D NMR (COSY, HMQC, HMBC and NOESY) spectroscopic data analyzes, and the structures of 1 and 9 were confirmed by X-ray crystallography. The inhibitory activities on LPS-induced NO production of these diterpenes were evaluated and all the compounds showed inhibitory effects.

Original language	English
Pages (from-to)	3612-3618
Number of pages	7
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	22
Issue number	11
DOIs	https://doi.org/10.1016/j.bmcl.2012.04.052
Publication status	Published - 2012 Jun 1

Keywords

Euphorbia prolifera
Inhibitory activities on NO production
Myrsinol diterpene

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Access to Document

10.1016/j.bmcl.2012.04.052

Cite this

New myrsinol diterpenes from Euphorbia prolifera and their inhibitory activities on LPS-induced NO production. / Xu, Jing; Jin, Da Qing; Guo, Yuanqiang; Xie, Chunfeng; Ma, Yonggang; Yamakuni, Tohru; Ohizumi, Yasushi.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 22, No. 11, 01.06.2012, p. 3612-3618.

Research output: Contribution to journal › Article › peer-review

@article{5a1270c019b0400397e7ce219de10db3,

title = "New myrsinol diterpenes from Euphorbia prolifera and their inhibitory activities on LPS-induced NO production",

abstract = "A phytochemical investigation of the roots of Euphorbia prolifera led to the isolation of ten new myrsinol diterpenes, named euphorbialoids A-J (1-10), and two known analogues (11 and 12). Their structures were elucidated on the basis of extensive 1D and 2D NMR (COSY, HMQC, HMBC and NOESY) spectroscopic data analyzes, and the structures of 1 and 9 were confirmed by X-ray crystallography. The inhibitory activities on LPS-induced NO production of these diterpenes were evaluated and all the compounds showed inhibitory effects.",

keywords = "Euphorbia prolifera, Inhibitory activities on NO production, Myrsinol diterpene",

author = "Jing Xu and Jin, {Da Qing} and Yuanqiang Guo and Chunfeng Xie and Yonggang Ma and Tohru Yamakuni and Yasushi Ohizumi",

note = "Funding Information: The project was supported by the Natural Science Foundation of China (No. 81102331), and the Natural Science Foundation of Tianjin (No. 08JCYBJC07200), China. ",

year = "2012",

month = jun,

day = "1",

doi = "10.1016/j.bmcl.2012.04.052",

language = "English",

volume = "22",

pages = "3612--3618",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "11",

}

TY - JOUR

T1 - New myrsinol diterpenes from Euphorbia prolifera and their inhibitory activities on LPS-induced NO production

AU - Xu, Jing

AU - Jin, Da Qing

AU - Guo, Yuanqiang

AU - Xie, Chunfeng

AU - Ma, Yonggang

AU - Yamakuni, Tohru

AU - Ohizumi, Yasushi

N1 - Funding Information: The project was supported by the Natural Science Foundation of China (No. 81102331), and the Natural Science Foundation of Tianjin (No. 08JCYBJC07200), China.

PY - 2012/6/1

Y1 - 2012/6/1

N2 - A phytochemical investigation of the roots of Euphorbia prolifera led to the isolation of ten new myrsinol diterpenes, named euphorbialoids A-J (1-10), and two known analogues (11 and 12). Their structures were elucidated on the basis of extensive 1D and 2D NMR (COSY, HMQC, HMBC and NOESY) spectroscopic data analyzes, and the structures of 1 and 9 were confirmed by X-ray crystallography. The inhibitory activities on LPS-induced NO production of these diterpenes were evaluated and all the compounds showed inhibitory effects.

AB - A phytochemical investigation of the roots of Euphorbia prolifera led to the isolation of ten new myrsinol diterpenes, named euphorbialoids A-J (1-10), and two known analogues (11 and 12). Their structures were elucidated on the basis of extensive 1D and 2D NMR (COSY, HMQC, HMBC and NOESY) spectroscopic data analyzes, and the structures of 1 and 9 were confirmed by X-ray crystallography. The inhibitory activities on LPS-induced NO production of these diterpenes were evaluated and all the compounds showed inhibitory effects.

KW - Euphorbia prolifera

KW - Inhibitory activities on NO production

KW - Myrsinol diterpene

UR - http://www.scopus.com/inward/record.url?scp=84861195655&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84861195655&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2012.04.052

DO - 10.1016/j.bmcl.2012.04.052

M3 - Article

C2 - 22560584

AN - SCOPUS:84861195655

VL - 22

SP - 3612

EP - 3618

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 11

ER -

New myrsinol diterpenes from Euphorbia prolifera and their inhibitory activities on LPS-induced NO production

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this