New multidrug resistance modulators from Atractylodis Lanceae Rhizoma

Nobutoshi Murakami, Etsuko Iwata, Satoru Tamura, Shin ichi Akiyama, Motomasa Kobayashi

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Three new oligoacylated sucroses designated atractysucroses-I, -II, and -III were obtained from Atractylodis Lanceae Rhizoma as multidrug resistance (MDR) modulating substances against human carcinoma cell lines and their chemical structures were characterized as a mixture of acyl groups. Atractysucrose-I modulates MDR in KB-C2 cells as strongly as verapamil. This is the first example of an MDR-modulator classified as a carbohydrate. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)2629-2632
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume10
Issue number23
DOIs
Publication statusPublished - 2000 Dec 4

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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