TY - JOUR
T1 - New multidrug resistance modulators from Atractylodis Lanceae Rhizoma
AU - Murakami, Nobutoshi
AU - Iwata, Etsuko
AU - Tamura, Satoru
AU - Akiyama, Shin ichi
AU - Kobayashi, Motomasa
N1 - Funding Information:
The authors are grateful to the Naito Foundation, the Houansha Foundation, and the Ministry of Education, Science, Sports, and Culture of Japan for financial support.
PY - 2000/12/4
Y1 - 2000/12/4
N2 - Three new oligoacylated sucroses designated atractysucroses-I, -II, and -III were obtained from Atractylodis Lanceae Rhizoma as multidrug resistance (MDR) modulating substances against human carcinoma cell lines and their chemical structures were characterized as a mixture of acyl groups. Atractysucrose-I modulates MDR in KB-C2 cells as strongly as verapamil. This is the first example of an MDR-modulator classified as a carbohydrate. (C) 2000 Elsevier Science Ltd.
AB - Three new oligoacylated sucroses designated atractysucroses-I, -II, and -III were obtained from Atractylodis Lanceae Rhizoma as multidrug resistance (MDR) modulating substances against human carcinoma cell lines and their chemical structures were characterized as a mixture of acyl groups. Atractysucrose-I modulates MDR in KB-C2 cells as strongly as verapamil. This is the first example of an MDR-modulator classified as a carbohydrate. (C) 2000 Elsevier Science Ltd.
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U2 - 10.1016/S0960-894X(00)00536-9
DO - 10.1016/S0960-894X(00)00536-9
M3 - Article
C2 - 11128639
AN - SCOPUS:0034606473
VL - 10
SP - 2629
EP - 2632
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 23
ER -